Definition
Enzymatic activity that catalyzes the decomposition of adenosine triphosphate (ATP) into adenosine diphosphate (ADP) and phosphate (Pi). A protein with ATPase activity.
Overview
The term ATPase applies to the activity of any enzyme’s ability to decompose ATP, including metabolic enzymes involved in anabolic processes that need energy, as well as enzymes promoting transport across membrane. In the former case, the enzyme decomposes ATP using the energy liberated to do work; for instance, enzymes such as DNA helicases, RecA protein, AAA proteins, or the muscle contraction protein myosin hydrolyze ATP, applying the liberated free energy directly to their functions. In other cases, i.e., glutamine synthetase, decomposition of ATP is performed in two steps, helping to perform chemical work, phosphorylating a substrate or enzyme in a first step, and releasing the Pi in a second step. Sometimes...
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References and Further Reading
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Abad, J.P. (2014). ATPase. In: Amils, R., et al. Encyclopedia of Astrobiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27833-4_135-2
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DOI: https://doi.org/10.1007/978-3-642-27833-4_135-2
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