LAMA1 (Laminin Alpha 1) is a laminin subunit, part of a family of extracellular matrix glycoproteins that form a major component of the basement membrane and are implicated in numerous processes including cellular differentiation, adhesion, migration, signaling, neurite outgrowth, embryogenesis and metastasis. Mutations in LAMA1 are associated with Poretti-Boltshauser syndrome, described by cerebellar dysplasia with cysts and malformation of the fourth ventricle. In immunohistochemistry, Laminin antibodies can be used in conjunction with cytokeratin antibodies to detect microinvasion in cervival and vulvar intraepithelial neoplasia. In normal tissue, LAMA1 has membranous positivity in tubules in the testes and lower levels of expression in various tissues throughout the body. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Eur J Hum Genet. 2016 Aug; 24(9): 1262–1267, PMID: 26932191; Arch Pathol Lab Med. 2005 Jun;129(6):747-53, PMID: 15913422