blue Fugates of Kentucky

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Click here for photos and the whole story►►►► A blue-skinned family lived in Kentucky in the 1800s. “The Blue Fugates” had a condition called methemoglobinemia that limits oxygen in the body’s tissues. Because of the family’s inbreeding, many of them had blue skin.

What Will Future Humans Look Like?

What Will Future Humans Look Like? It really happened: six generations of inbreeding spanning the years 1800 to 1960 caused an isolated population of humans living in the hills of Kentucky to become blue-skinned. The startlingly blue people, all descendants of a French immigrant named Martin Fugate and still living near his original settlement on the banks of Troublesome Creek when hematologists studied them in the 1960s, turned out to have a rare blood condition called methemoglobinemia.

Indiana University Bloomington

Indiana University Bloomington

The Blue People of Troublesome Creek: more on the Fugate family.

Blue People of Kentucky: Why the Fugate Family Had Blue Skin

Blue People in Kentucky: The True Story of the Fugate Family with Blue Skin

"Blue Skin: Sometimes It's Genetic." Not a lesson plan, but great reading! Learn the two main ways that people acquire a blue skin tone. The first link shows a photo of the genetically blue-skinned Fugate family from Kentucky. #biology #genetics #weird #science Health, Biology, Geneology, Genealogy, Skin Tone, Medical, Medical History, Mitosis

"Blue Skin: Sometimes It's Genetic." Not a lesson plan, but great reading! Learn the two main ways that people acquire a blue skin tone. The first link shows a photo of the genetically blue-skinned Fugate family from Kentucky. #biology #genetics #weird #science

Tay-Sachs disease: results from the absence of an active lysosomal enzyme called hexosaminidase A, whose lack leads to the accumulation of a toxic waste product inside nerve cells; newborns healthy for 5-6 mths, then develop blindness, paralysis, mental retardation, fatal by age 6; recessive allele that result in lethality after birth Ejercicio, Situs Inversus, Syndrome, Salud, Congenital Adrenal Hyperplasia, Diagnosis, Disease

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Tay-Sachs disease: results from the absence of an active lysosomal enzyme called hexosaminidase A, whose lack leads to the accumulation of a toxic waste product inside nerve cells; newborns healthy for 5-6 mths, then develop blindness, paralysis, mental retardation, fatal by age 6; recessive allele that result in lethality after birth

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Blue-skinned people of Kentucky: Fugate family were inbreeders

Blue People of Kentucky, Appalachia

(Blue People of Kentucky) Fugates: The genetic form of methemoglobinemia is caused by one of several genetic defects. The Fugates probably had a deficiency in the enzyme called cytochrome-b5 methemoglobin reductase, which is responsible for recessive congenital methemoglobinemia. At levels of between 10 and 20 percent a person can develop blue skin without any other symptoms. Most of blue Fugates never suffered any health effects and lived into their 80s and 90s.

The Blue People of Troublesome Creek, Kentucky ~ a result of hereditary methemoglobinemia... Martin Fugate carried the recessive gene and the odds that he could have married a woman with the same recessive gene were overwhelming - but that is exactly what happened. (sometime around 1820) ...due to interbreeding, blue skinned Fugates continued for generations. Medical Oddities, Medical Problems, Medical Conditions, Weird, Disturbing

The Blue People of Troublesome Creek, Kentucky

The Blue People of Troublesome Creek, Kentucky ~ a result of hereditary methemoglobinemia... Martin Fugate carried the recessive gene and the odds that he could have married a woman with the same recessive gene were overwhelming - but that is exactly what happened. (sometime around 1820) ...due to interbreeding, blue skinned Fugates continued for generations.